TMEM168

Across TCGA pan-cancer cohorts, TMEM168 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TMEM168 data layer compared with 8 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TMEM168 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TMEM168 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

KIRC, UVM, and KICH are the cancer types where TMEM168 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.713	0.550	<.001	73	view →
UVM	OS	Median	III,IV	0.395	0.903	.001	67	view →
KICH	DFS	Tertile	II,III,IV	0.499	0.958	.001	59	view →
LGG	DFS	Median	All	0.658	0.818	<.001	53	view →
UCS	OS	Median	II,III,IV	0.668	0.372	.019	40	view →
LUAD	OS	Quartile	II,III,IV	0.752	0.484	.008	26	view →
LUSC	OS	Median	All	0.814	0.732	.002	26	view →
SCLC	OS	Tertile	All	0.605	1.000	.020	17	view →
LIHC	OS	Tertile	All	0.685	0.821	.004	16	view →
STAD	DFS	Quartile	IV	0.204	0.663	.017	15	view →
THCA	OS	Quartile	II,III,IV	0.654	0.875	.016	11	view →
HNSC	OS	Quartile	All	0.841	0.706	.011	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TMEM168–KIRC (OS)

Open the KIRC breakdown →