TMEM168

Across TCGA patient cohorts, TMEM168 mutation is significantly associated with the RNA expression of many other genes, with 2,403 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM168-associated genes across cancer lineages are ZNF736P7Y, MIR549A, and MIR3135A. Each is linked with TMEM168 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM168-to-partner and partner-to-TMEM168 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF736P7Y grouped by TMEM168-low versus TMEM168-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM168→partner) and Y-score (partner→TMEM168) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	ZNF736P7Y →	+0.065	+6.676	<.001	<.001	3	3
READ	MIR549A →	+0.708	+4.653	<.001	.007	3	3
CESC	MIR3135A →	+0.648	+4.503	<.001	.005	3	3
UCEC	H2AZ1 →	+0.604	+2.787	<.001	<.001	3	3
UCEC	CDT1 →	+0.829	+2.091	<.001	<.001	3	3
UCEC	HDHD5 →	+0.390	+1.545	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,403 associations by consensus.

ZNF736P7Y by TMEM168 expression — LIHC

Explore this box plot interactively →