TMEM168

Across TCGA patient cohorts, TMEM168 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM168-associated genes across cancer lineages are ATM, Notch1, and PDCD4. Each is linked with TMEM168 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM168-to-partner and partner-to-TMEM168 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TMEM168-low versus TMEM168-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM168→partner) and Y-score (partner→TMEM168) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.397	-1.362	.013	.037	3	3
UCEC	Notch1 →	+0.123	+1.362	.013	.037	3	2
UCEC	PDCD4 →	-0.355	-2.000	.032	.003	3	2
UCEC	Rab25 →	-0.341	-2.115	.003	.016	3	2
UCEC	Shc_pY317 →	-0.226	-2.999	<.001	<.001	3	2
UCEC	VHL →	-1.167	-3.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

ATM by TMEM168 expression — UCEC

Explore this box plot interactively →