TMEM168

Across TCGA cell cohorts, TMEM168 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,776 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TMEM168-associated GO terms across cancer lineages are Pre-mRNA catabolic process, Glycerophospholipid biosynthetic process, and Intra-Golgi vesicle-mediated transport. Each is linked with TMEM168 in more than 11 cancer types. Because this analysis shows association rather than direction, both TMEM168-to-partner and partner-to-TMEM168 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pre-mRNA catabolic process grouped by TMEM168-low versus TMEM168-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM168→partner) and Y-score (partner→TMEM168) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Pre-mRNA catabolic process →	+0.188	+0.545	<.001	.003	3	12
UPPER_AERODIGESTIVE_TRACT	Glycerophospholipid biosynthetic process →	+0.039	+1.087	<.001	<.001	3	11
PANCREAS	Intra-Golgi vesicle-mediated transport →	+0.081	+1.538	.003	.004	3	11
BLOOD_Lymphoma	Viral translational termination-reinitiation →	+0.092	+1.146	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Glycerolipid biosynthetic process →	+0.048	+1.289	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Phospholipid biosynthetic process →	+0.040	+0.953	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,776 associations by consensus.

Pre-mRNA catabolic process by TMEM168 expression — BONE

Explore this box plot interactively →