TMEM168

Across TCGA cell cohorts, TMEM168 mutation is significantly associated with the drug of many other genes, with 33 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM168-associated genes across cancer lineages are Ara-G, TL-2-105, and Cabozantinib. Each is linked with TMEM168 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM168-to-partner and partner-to-TMEM168 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ara-G grouped by TMEM168-low versus TMEM168-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM168→partner) and Y-score (partner→TMEM168) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Ara-G →	+0.732	+2.641	.010	.049	3	2
BLOOD_Lymphoma	TL-2-105 →	+0.402	+2.658	.011	.043	3	1
BLOOD_Lymphoma	Cabozantinib →	+0.393	+3.013	.036	.019	2	2
LARGE_INTESTINE	Niraparib →	+0.457	+2.646	.009	.047	3	1
LARGE_INTESTINE	Luminespib →	+0.679	+2.646	.025	.047	3	1
LARGE_INTESTINE	AZD5153 →	+0.681	+2.649	.006	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Ara-G by TMEM168 expression — BLOOD_Leukemia

Explore this box plot interactively →