TMEM167A

Across TCGA patient cohorts, TMEM167A mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM167A-associated genes across cancer lineages are PGBD4P2, OR10AE1P, and RNA5SP113. Each is linked with TMEM167A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM167A-to-partner and partner-to-TMEM167A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGBD4P2 grouped by TMEM167A-low versus TMEM167A-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM167A→partner) and Y-score (partner→TMEM167A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	PGBD4P2 →	+0.217	+6.257	<.001	.001	3	2
READ	OR10AE1P →	+0.189	+6.681	<.001	<.001	3	2
UCEC	RNA5SP113 →	+0.716	+4.226	<.001	.008	3	2
UCEC	USP12PY →	+0.043	+4.226	<.001	.008	3	2
BRCA	RNU6-426P →	+0.373	+9.057	<.001	.003	3	1
BRCA	MIR4498 →	+0.522	+8.055	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

PGBD4P2 by TMEM167A expression — READ

Explore this box plot interactively →