TMEM164

Across TCGA patient cohorts, TMEM164 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM164-associated genes across cancer lineages are Rab25, c-Kit, and 14-3-3_beta. Each is linked with TMEM164 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM164-to-partner and partner-to-TMEM164 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by TMEM164-low versus TMEM164-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM164→partner) and Y-score (partner→TMEM164) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.334	-2.222	.003	.010	3	2
UCEC	c-Kit →	-0.184	-1.440	.023	.024	3	2
UCEC	14-3-3_beta →	-0.077	-2.432	.026	.018	3	1
UCEC	eEF2 →	+0.456	+4.000	<.001	<.001	3	1
UCEC	EGFR_pY1068 →	-0.316	-2.662	<.001	<.001	3	1
UCEC	eIF4E →	+0.155	+2.222	.034	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Rab25 by TMEM164 expression — UCEC

Explore this box plot interactively →