TMEM164

Across TCGA pan-cancer cohorts, TMEM164 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TMEM164’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TMEM164 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM164 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and LIHC are the cancer types where TMEM164 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM164 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.379	<.001	12	view →
THCA	Male	III,IV	−1.920	<.001	10	view →
LIHC	Female	All	+1.639	<.001	9	view →
LUAD	Female	III,IV	−1.187	<.001	9	view →
STAD	All	II,III,IV	+1.353	<.001	8	view →
KICH	All	All	−1.025	<.001	7	view →
LUSC	Male	All	−0.824	<.001	6	view →
HNSC	Male	All	+0.548	.001	6	view →
COAD	Female	II,III,IV	−0.673	<.001	5	view →
KIRP	Male	All	−0.865	<.001	4	view →
PAAD	All	All	+0.652	.010	4	view →
CHOL	Male	All	+2.836	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TMEM164–KIRC

Open the KIRC breakdown →