TMEM161B-AS1

Across TCGA pan-cancer cohorts, TMEM161B-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated TMEM161B-AS1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher TMEM161B-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM161B-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and PAAD show a favorable association.

KICH, ACC, and OV are the cancer types where TMEM161B-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	II,III,IV	0.677	1.000	.001	85	view →
ACC	OS	Quartile	All	0.779	1.000	.002	50	view →
OV	DFS	Median	II,III,IV	0.124	0.192	.008	44	view →
UVM	OS	Median	All	0.403	0.890	.001	34	view →
LIHC	DFS	Tertile	All	0.396	0.626	<.001	33	view →
KIRP	DFS	Median	II,III,IV	1.000	0.322	.002	32	view →
PAAD	OS	Median	All	0.496	0.228	.003	31	view →
LGG	DFS	Quartile	All	0.754	0.862	.003	22	view →
BLCA	OS	Median	II,III,IV	0.529	0.356	.006	20	view →
PRAD	DFS	Median	All	0.677	0.885	<.001	18	view →
ESCA	OS	Median	All	0.388	0.577	.015	14	view →
READ	OS	Quartile	II,III,IV	0.748	0.426	.016	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

TMEM161B-AS1–KICH (DFS)

Open the KICH breakdown →