TMEM156

Across TCGA patient cohorts, TMEM156 mutation is significantly associated with the RNA expression of many other genes, with 1,094 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM156-associated genes across cancer lineages are RNA5SP369, SAGE3P, and PRC1. Each is linked with TMEM156 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM156-to-partner and partner-to-TMEM156 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP369 grouped by TMEM156-low versus TMEM156-high in OV.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM156→partner) and Y-score (partner→TMEM156) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RNA5SP369 →	+0.254	+6.036	<.001	.002	3	3
OV	SAGE3P →	+0.051	+5.787	<.001	.003	3	2
UCEC	PRC1 →	+0.842	+3.201	.005	.009	3	2
UCEC	RPL23AP7 →	+0.486	+3.266	.005	.008	3	2
UCEC	MTFMT →	+0.521	+3.459	.001	.005	3	2
UCEC	NSMCE4A →	+0.609	+3.332	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,094 associations by consensus.

RNA5SP369 by TMEM156 expression — OV

Explore this box plot interactively →