TMEM150A

Across TCGA patient cohorts, TMEM150A mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM150A-associated genes across cancer lineages are FOXO3a_pS318_S321, Acetyl-a-Tubulin-Lys40, and Lck. Each is linked with TMEM150A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM150A-to-partner and partner-to-TMEM150A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by TMEM150A-low versus TMEM150A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM150A→partner) and Y-score (partner→TMEM150A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.138	-2.321	.027	.035	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.741	+3.459	.003	.005	3	1
UCEC	Lck →	+0.274	+3.459	.006	.005	3	1
UCEC	mTOR_pS2448 →	-0.163	-2.980	.029	.036	3	1
UCEC	Annexin-1 →	+0.612	+2.827	.020	.035	3	1
UCEC	STAT3_pY705 →	-0.424	-2.321	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

FOXO3a_pS318_S321 by TMEM150A expression — UCEC

Explore this box plot interactively →