transmembrane protein 14D, pseudogeneGenealiases: TMEM14D · bA524O24.3
Q-omics provides the consensus-scored TMEM14DP profile across patient tissues and cancer cell-line models. TMEM14DP expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in UCS. Among the 18 cancer types available for tumor–normal comparison, TMEM14DP is differentially expressed in 8, with the highest sampling consensus in COAD. Additionally, TMEM14DP RNA expression shows 13,143 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UCS, COAD, and UVM as cancer lineages where TMEM14DP shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TMEM14DP — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TMEM14DP survival associations across molecular data types. TMEM14DP RNA expression shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TMEM14DP RNA expression–survival associations across cancer types. High TMEM14DP expression shows unfavorable associations in UVM, CESC, PAAD and LIHC, but favorable associations in UCS and KIRC. The UCS Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .018). Together, the overview and detailed table identify UCS as the clearest survival context for TMEM14DP RNA expression.
This table summarizes TMEM14DP tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for TMEM14DP. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TMEM14DP shows lower tumor expression in KIRP, THCA and KICH and higher tumor expression in COAD, LUAD and LIHC. The COAD box plot shows higher TMEM14DP RNA expression in tumor versus normal tissue (log2 FC = +1.076, t-test p < 0.001).
This table shows molecular features associated with TMEM14DP in patient tissues and cancer cell lines. In patient samples, TMEM14DP shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
