TMEM14C

Across TCGA pan-cancer cohorts, TMEM14C Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TMEM14C data layer compared with 22 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher TMEM14C Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM14C expression acts as an unfavorable survival marker.

BLCA and LGG are the cancer types where TMEM14C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.186	0.711	<.001	36	view →
LGG	DFS	Median	All	0.110	0.833	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

TMEM14C–BLCA (OS)

Open the BLCA breakdown →