TMEM14C

Across TCGA pan-cancer cohorts, TMEM14C mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TMEM14C data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TMEM14C mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM14C expression acts as an unfavorable survival marker.

CCRCC and LUAD are the cancer types where TMEM14C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.754	1.000	.004	22	view →
LUAD	OS	Tertile	All	0.358	0.851	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

TMEM14C–CCRCC (OS)

Open the CCRCC breakdown →