TMEM147

Across TCGA pan-cancer cohorts, TMEM147 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TMEM147 data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMEM147 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM147 expression acts as an unfavorable survival marker.

HNSC, SKCM, and CESC are the cancer types where TMEM147 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.144	0.627	.007	24	view →
SKCM	DFS	Median	II,III,IV	0.078	0.691	<.001	24	view →
CESC	DFS	Median	II,III,IV	0.215	0.711	.010	18	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TMEM147–HNSC (DFS)

Open the HNSC breakdown →