TMEM147

Across TCGA pan-cancer cohorts, TMEM147 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TMEM147’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where TMEM147 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM147 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

BLCA, COAD, and LIHC are the cancer types where TMEM147 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM147 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	+1.276	<.001	12	view →
COAD	Female	III,IV	+1.883	<.001	11	view →
LIHC	Female	II,III,IV	+1.679	<.001	9	view →
LUAD	All	III,IV	+0.901	<.001	9	view →
STAD	All	II,III,IV	+0.620	<.001	9	view →
UCEC	All	III,IV	+1.065	<.001	8	view →
KIRP	All	II,III,IV	+0.484	<.001	7	view →
BRCA	All	III,IV	+0.876	<.001	6	view →
LUSC	All	II,III,IV	+0.761	<.001	6	view →
CHOL	Male	All	+2.443	<.001	5	view →
READ	All	All	+0.993	<.001	5	view →
ESCA	All	All	+0.846	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TMEM147–BLCA

Open the BLCA breakdown →