TMEM147

Across TCGA pan-cancer cohorts, TMEM147 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TMEM147 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMEM147 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM147 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, COAD, and CCRCC are the cancer types where TMEM147 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.821	0.495	<.001	46	view →
COAD	DFS	Median	All	0.900	1.000	.044	12	view →
CCRCC	OS	Median	All	0.613	0.985	.017	7	view →
LUAD	OS	Tertile	II,III,IV	0.868	0.380	.017	7	view →
GBM	DFS	Median	All	0.250	0.469	.005	4	view →
UCEC	DFS	Median	All	0.857	0.977	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TMEM147–HNSC (DFS)

Open the HNSC breakdown →