TMEM147

Across TCGA patient cohorts, TMEM147 mutation is significantly associated with the RNA expression of many other genes, with 1,048 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM147-associated genes across cancer lineages are RNU6-694P, RNA5SP415, and RNU7-53P. Each is linked with TMEM147 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM147-to-partner and partner-to-TMEM147 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-694P grouped by TMEM147-low versus TMEM147-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM147→partner) and Y-score (partner→TMEM147) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-694P →	+0.265	+4.308	.002	.009	3	2
UCEC	RNA5SP415 →	+0.982	+3.488	<.001	<.001	3	2
BLCA	RNU7-53P →	+0.778	+7.640	<.001	.009	3	1
UCEC	ZNHIT3 →	+0.597	+3.721	<.001	<.001	3	1
UCEC	RNA5SP414 →	+1.098	+3.255	<.001	<.001	3	1
UCEC	ZNF280B →	+0.584	+2.595	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,048 associations by consensus.

RNU6-694P by TMEM147 expression — COAD

Explore this box plot interactively →