TMEM147

Across TCGA patient cohorts, TMEM147 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM147-associated genes across cancer lineages are Annexin-1, VHL, and ATM. Each is linked with TMEM147 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM147-to-partner and partner-to-TMEM147 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by TMEM147-low versus TMEM147-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM147→partner) and Y-score (partner→TMEM147) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.684	+3.019	.009	.019	3	1
UCEC	VHL →	-1.266	-2.321	<.001	.035	3	1
UCEC	ATM →	-0.558	-2.321	.014	.035	3	1
UCEC	Caspase-8 →	-0.316	-3.459	.012	.005	2	1
UCEC	MEK1 →	+0.564	+3.459	.002	.005	1	1
UCEC	Notch1 →	+0.305	+2.321	<.001	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Annexin-1 by TMEM147 expression — UCEC

Explore this box plot interactively →