TMEM145

Across TCGA patient cohorts, TMEM145 protein abundance is significantly associated with the RNA expression of many other genes, with 280 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMEM145-associated genes across cancer lineages are LIN7B, PLA2G4C, and ARHGAP21. Each is linked with TMEM145 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM145-to-partner and partner-to-TMEM145 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM145 versus LIN7B in GBM, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM145→partner) and Y-score (partner→TMEM145) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LIN7B →	+0.515	+0.553	.001	.005	3	1
GBM	PLA2G4C →	+0.874	+0.799	.001	<.001	3	1
GBM	ARHGAP21 →	+0.578	+0.773	.002	.001	3	1
GBM	MPP2 →	+0.726	+0.457	<.001	.001	3	1
GBM	DHRS7B →	-0.331	-0.608	<.001	<.001	3	1
GBM	GMDS →	-0.360	-0.516	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 280 associations by consensus.

TMEM145 vs LIN7B — GBM

Explore this scatter interactively →