TMEM145

Across TCGA patient cohorts, TMEM145 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM145-associated genes across cancer lineages are p53, C-Raf_pS338, and IGFBP2. Each is linked with TMEM145 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM145-to-partner and partner-to-TMEM145 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p53 grouped by TMEM145-low versus TMEM145-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM145→partner) and Y-score (partner→TMEM145) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p53 →	-0.337	-2.999	.040	.035	3	2
LUAD	C-Raf_pS338 →	+0.126	+2.841	.041	.035	3	1
UCEC	IGFBP2 →	-0.553	-2.321	.045	.034	3	1
UCEC	MEK1 →	+0.323	+4.000	.037	<.001	3	1
UCEC	PDK1_pS241 →	+0.157	+2.459	.030	.019	3	1
UCEC	PKC-delta_pS664 →	-0.108	-2.449	.033	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

p53 by TMEM145 expression — UCEC

Explore this box plot interactively →