TMEM145

Across TCGA cell cohorts, TMEM145 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TMEM145-associated genes across cancer lineages are MRAP, IFIT1B, and OPRM1. Each is linked with TMEM145 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM145-to-partner and partner-to-TMEM145 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRAP grouped by TMEM145-low versus TMEM145-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM145→partner) and Y-score (partner→TMEM145) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MRAP →	+0.073	+4.807	<.001	.006	3	1
BLOOD_Myeloma	IFIT1B →	+0.013	+4.807	<.001	.006	3	1
SKIN	OPRM1 →	+0.012	+3.684	<.001	.006	3	1
SKIN	MEPE →	+0.022	+3.920	<.001	.005	3	1
SKIN	FCN2 →	+0.036	+4.437	<.001	.004	3	1
SKIN	SLC13A1 →	+0.016	+4.688	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

MRAP by TMEM145 expression — BLOOD_Myeloma

Explore this box plot interactively →