TMEM143

Across TCGA patient cohorts, TMEM143 mutation is significantly associated with the RNA expression of many other genes, with 2,068 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM143-associated genes across cancer lineages are RN7SKP221, MIR557, and MIR4725. Each is linked with TMEM143 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM143-to-partner and partner-to-TMEM143 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP221 grouped by TMEM143-low versus TMEM143-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM143→partner) and Y-score (partner→TMEM143) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SKP221 →	+0.065	+7.471	<.001	.008	3	2
LGG	MIR557 →	+0.348	+7.977	<.001	.007	3	2
COAD	MIR4725 →	+0.263	+4.251	<.001	.008	3	2
BLCA	MIR4783 →	+0.485	+4.369	.008	.002	3	2
BLCA	MIR3912 →	+0.291	+4.266	.004	.003	3	2
SKCM	RN7SL163P →	+0.142	+3.408	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,068 associations by consensus.

RN7SKP221 by TMEM143 expression — BRCA

Explore this box plot interactively →