TMEM139

Across TCGA patient cohorts, TMEM139 mutation is significantly associated with the RNA expression of many other genes, with 1,863 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM139-associated genes across cancer lineages are RNA5SP411, RNA5SP419, and RNA5SP418. Each is linked with TMEM139 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM139-to-partner and partner-to-TMEM139 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by TMEM139-low versus TMEM139-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM139→partner) and Y-score (partner→TMEM139) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+1.112	+2.393	<.001	.001	3	2
UCEC	RNA5SP419 →	+0.706	+2.714	<.001	<.001	3	2
UCEC	RNA5SP418 →	+0.658	+2.126	<.001	.007	3	2
UCEC	RNA5SP417 →	+0.519	+2.214	<.001	.009	3	2
LUSC	RNA5SP416 →	+0.616	+4.733	<.001	.004	3	2
LUSC	RNA5SP415 →	+0.715	+4.733	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,863 associations by consensus.

RNA5SP411 by TMEM139 expression — UCEC

Explore this box plot interactively →