TMEM139

Across TCGA pan-cancer cohorts, TMEM139 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TMEM139 data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMEM139 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TMEM139 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

HNSC, PAAD, and KIRC are the cancer types where TMEM139 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	IV	0.767	0.545	.002	93	view →
PAAD	DFS	Tertile	All	0.367	0.642	<.001	85	view →
KIRC	DFS	Tertile	All	0.705	0.488	<.001	77	view →
THCA	DFS	Median	All	0.893	0.762	<.001	47	view →
KIRP	OS	Median	II,III,IV	0.869	0.584	.001	35	view →
COAD	DFS	Median	III,IV	0.543	0.746	.004	32	view →
UCS	DFS	Tertile	IV	0.938	0.237	.024	30	view →
LUSC	DFS	Median	III,IV	0.422	0.883	.008	29	view →
LGG	OS	Quartile	All	0.839	0.941	<.001	19	view →
LIHC	DFS	Quartile	All	0.423	0.549	.025	16	view →
ACC	DFS	Median	IV	0.594	0.151	.003	15	view →
READ	DFS	Median	II,III,IV	0.864	0.547	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TMEM139–HNSC (OS)

Open the HNSC breakdown →