TMEM139

Across TCGA patient cohorts, TMEM139 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM139-associated genes across cancer lineages are 14-3-3_beta, Heregulin, and IGFBP2. Each is linked with TMEM139 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM139-to-partner and partner-to-TMEM139 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by TMEM139-low versus TMEM139-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM139→partner) and Y-score (partner→TMEM139) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.134	-3.149	.005	.019	3	1
UCEC	Heregulin →	-0.162	-3.156	.006	.018	3	1
UCEC	IGFBP2 →	-0.908	-3.584	.003	.002	3	1
UCEC	p90 RSK →	+0.185	+3.179	.045	.010	3	1
UCEC	Rad50 →	-0.251	-2.459	.032	.020	3	1
UCEC	VHL →	-0.875	-3.321	.007	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

14-3-3_beta by TMEM139 expression — UCEC

Explore this box plot interactively →