TMEM139

Across TCGA cell cohorts, TMEM139 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,974 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM139-associated GO terms across cancer lineages are Regulation of determination of dorsal identity, Regulation of protein localization to cell periphery, and Serotonin receptor signaling pathway. Each is linked with TMEM139 in more than 7 cancer types. Because this analysis shows association rather than direction, both TMEM139-to-partner and partner-to-TMEM139 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of determination of dorsal identity grouped by TMEM139-low versus TMEM139-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM139→partner) and Y-score (partner→TMEM139) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of determination of dorsal identity →	-0.153	-2.047	.001	.005	3	8
OVARY	Regulation of protein localization to cell periphery →	+0.107	+3.092	<.001	<.001	3	8
BREAST	Serotonin receptor signaling pathway →	+0.208	+2.474	.006	.001	3	8
PANCREAS	Cell-substrate adhesion →	+0.123	+3.188	<.001	<.001	3	8
PANCREAS	Regulation of muscle filament sliding →	+1.441	+2.734	<.001	<.001	3	8
PANCREAS	Regulation of glycoprotein biosynthetic process →	+0.130	+2.756	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,974 associations by consensus.

Regulation of determination of dorsal identity by TMEM139 expression — STOMACH

Explore this box plot interactively →