TMEM139

Across TCGA cell cohorts, TMEM139 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. BLOOD_Myeloma shows the largest number of these associations.

The most reproducible TMEM139-associated genes across cancer lineages are CNGA3 and SLC22A24. Each is linked with TMEM139 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM139-to-partner and partner-to-TMEM139 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNGA3 grouped by TMEM139-low versus TMEM139-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM139→partner) and Y-score (partner→TMEM139) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CNGA3 →	+0.036	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SLC22A24 →	+0.013	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CNGA3 by TMEM139 expression — BLOOD_Myeloma

Explore this box plot interactively →