TMEM139-AS1

Across TCGA pan-cancer cohorts, TMEM139-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated TMEM139-AS1 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TMEM139-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM139-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and LAML show a favorable association.

COAD, UCS, and LGG are the cancer types where TMEM139-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.622	0.745	.007	36	view →
UCS	DFS	Median	IV	0.952	0.367	.001	24	view →
LGG	OS	Quartile	All	0.853	0.966	.001	16	view →
DLBC	OS	Tertile	All	0.656	1.000	.015	14	view →
UVM	DFS	Quartile	All	0.500	1.000	.008	13	view →
CHOL	OS	Median	IV	0.208	0.948	.010	12	view →
ACC	DFS	Median	All	0.551	0.760	.005	10	view →
LUSC	DFS	Quartile	III,IV	0.485	1.000	.010	10	view →
HNSC	DFS	Median	III,IV	0.191	0.385	.007	10	view →
LAML	DFS	Quartile	All	0.521	0.277	.011	10	view →
STAD	OS	Quartile	IV	0.846	0.384	.026	8	view →
OV	DFS	Quartile	IV	0.394	0.618	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

TMEM139-AS1–COAD (DFS)

Open the COAD breakdown →