TMEM139-AS1

Across TCGA pan-cancer cohorts, TMEM139-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TMEM139-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TMEM139-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM139-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and BLCA are the cancer types where TMEM139-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM139-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−0.317	<.001	7	view →
KICH	Female	II,III,IV	−0.361	<.001	6	view →
BLCA	All	IV	+0.180	.010	5	view →
COAD	Female	III,IV	+0.178	.008	5	view →
CHOL	All	All	+0.326	<.001	3	view →
READ	All	All	+0.191	.008	3	view →
LIHC	All	All	+0.060	.001	3	view →
LUAD	All	IV	+0.530	<.001	2	view →
BRCA	All	IV	+0.160	.045	2	view →
PRAD	All	All	+0.062	.015	2	view →
LUSC	Female	III,IV	−0.105	.002	1	view →
HNSC	All	IV	+0.080	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TMEM139-AS1–THCA

Open the THCA breakdown →