TMEM135

Across TCGA patient cohorts, TMEM135 protein abundance is significantly associated with the RNA expression of many other genes, with 5,945 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM135-associated genes across cancer lineages are DKC1, HDGFL3, and CDK6. Each is linked with TMEM135 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM135-to-partner and partner-to-TMEM135 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM135 versus DKC1 in LSCC, with a Pearson correlation of -0.24.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM135→partner) and Y-score (partner→TMEM135) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DKC1 →	-0.411	-0.172	.007	.007	3	3
OV	HDGFL3 →	-0.696	-0.361	<.001	<.001	3	3
GBM	CDK6 →	-0.933	-0.201	<.001	.003	3	3
UCEC	ZNF697 →	-0.676	-0.431	.007	.008	3	3
LSCC	SELENBP1 →	+1.103	+0.214	<.001	<.001	3	3
GBM	HSPB8 →	+1.232	+0.261	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,945 associations by consensus.

TMEM135 vs DKC1 — LSCC

Explore this scatter interactively →