TMEM135

Across TCGA pan-cancer cohorts, TMEM135 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TMEM135’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TMEM135 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM135 is over-expressed in tumor, although a few such as THCA and READ show the opposite, repressed pattern.

KIRC, THCA, and STAD are the cancer types where TMEM135 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM135 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+0.901	<.001	12	view →
THCA	Male	III,IV	−0.938	<.001	10	view →
STAD	All	II,III,IV	+0.829	<.001	7	view →
LIHC	Male	All	+0.650	<.001	7	view →
READ	All	All	−0.615	.002	7	view →
BLCA	All	III,IV	+0.567	.017	4	view →
LUAD	Male	All	+0.446	.003	3	view →
COAD	All	All	−0.374	.006	3	view →
KIRP	Female	II,III,IV	+0.514	.003	2	view →
PRAD	All	All	+0.410	.003	2	view →
BRCA	All	All	−0.201	.042	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TMEM135–KIRC

Open the KIRC breakdown →