TMEM135

Across TCGA patient cohorts, TMEM135 mutation is significantly associated with the RNA expression of many other genes, with 1,058 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM135-associated genes across cancer lineages are MIR557, CASP1P1, and SNORD114-12. Each is linked with TMEM135 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM135-to-partner and partner-to-TMEM135 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR557 grouped by TMEM135-low versus TMEM135-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM135→partner) and Y-score (partner→TMEM135) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR557 →	+0.273	+5.087	.003	.004	3	4
LUAD	CASP1P1 →	+0.290	+4.481	<.001	.009	3	3
HNSC	SNORD114-12 →	+0.276	+4.763	<.001	.004	3	2
HNSC	RNA5SP193 →	+0.270	+4.468	<.001	.006	3	2
HNSC	MED28P4 →	+0.070	+4.100	.006	.001	3	2
LUAD	SSX9P →	+0.723	+5.197	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,058 associations by consensus.

MIR557 by TMEM135 expression — LUAD

Explore this box plot interactively →