TMEM135

Across TCGA patient cohorts, TMEM135 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM135-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and ERK2. Each is linked with TMEM135 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM135-to-partner and partner-to-TMEM135 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by TMEM135-low versus TMEM135-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM135→partner) and Y-score (partner→TMEM135) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.102	-3.143	.016	.018	3	1
UCEC	eIF4E →	+0.215	+2.222	.016	.011	3	1
UCEC	ERK2 →	+0.197	+1.700	.016	.044	3	1
UCEC	Fibronectin →	-0.316	-1.990	.024	.030	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.409	+2.009	.024	.017	3	1
UCEC	JNK2 →	+0.247	+2.348	.003	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

14-3-3_beta by TMEM135 expression — UCEC

Explore this box plot interactively →