TMEM132E

Across TCGA patient cohorts, TMEM132E mutation is significantly associated with the total protein of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM132E-associated genes across cancer lineages are ASNS, Cyclin-E1, and Caveolin-1. Each is linked with TMEM132E in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM132E-to-partner and partner-to-TMEM132E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by TMEM132E-low versus TMEM132E-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM132E→partner) and Y-score (partner→TMEM132E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.574	+1.593	<.001	.043	3	4
COAD	Cyclin-E1 →	+0.319	+3.334	.001	.005	3	4
LUSC	Caveolin-1 →	-0.651	-3.000	.012	.033	3	3
COAD	eEF2 →	+0.427	+3.204	<.001	.008	3	3
UCEC	eIF4E →	+0.163	+2.515	.005	<.001	3	3
COAD	A-Raf_pS299 →	-0.185	-2.106	.005	.018	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

ASNS by TMEM132E expression — COAD

Explore this box plot interactively →