TMEM132E

Across TCGA cell cohorts, TMEM132E mutation is significantly associated with the RNA expression of many other genes, with 393 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM132E-associated genes across cancer lineages are PPIL4, C1orf52, and RBMY1J. Each is linked with TMEM132E in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM132E-to-partner and partner-to-TMEM132E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIL4 grouped by TMEM132E-low versus TMEM132E-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM132E→partner) and Y-score (partner→TMEM132E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPIL4 →	+0.555	+3.252	.002	.002	3	2
LARGE_INTESTINE	C1orf52 →	+0.557	+3.502	.005	.001	3	2
SKIN	RBMY1J →	+0.006	+4.977	<.001	.007	3	2
URINARY_TRACT	MAGEE2 →	+0.005	+4.087	<.001	.009	3	1
LUNG_NSCLC_LUSC	PIRT →	+0.006	+4.643	<.001	.008	3	1
STOMACH	HS3ST2 →	+0.059	+4.050	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 393 associations by consensus.

PPIL4 by TMEM132E expression — LARGE_INTESTINE

Explore this box plot interactively →