TMEM132C

Across TCGA patient cohorts, TMEM132C mutation is significantly associated with the RNA expression of many other genes, with 3,031 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM132C-associated genes across cancer lineages are NOVA1, MIR7-3, and SKA3. Each is linked with TMEM132C in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM132C-to-partner and partner-to-TMEM132C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOVA1 grouped by TMEM132C-low versus TMEM132C-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM132C→partner) and Y-score (partner→TMEM132C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	NOVA1 →	-1.441	-2.184	.008	.005	3	3
SARC	MIR7-3 →	+0.166	+5.403	<.001	<.001	3	3
UCEC	SKA3 →	+0.370	+1.108	.006	.007	3	3
UCEC	PLRG1 →	+0.328	+1.662	<.001	<.001	3	3
COAD	TIMM22 →	+0.423	+2.428	<.001	.002	3	3
UCEC	TIMM21 →	+0.369	+1.836	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,031 associations by consensus.

NOVA1 by TMEM132C expression — SCLC

Explore this box plot interactively →