TMEM132A

Across TCGA patient cohorts, TMEM132A mutation is significantly associated with the RNA expression of many other genes, with 4,954 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM132A-associated genes across cancer lineages are RFC5, CEP76, and RBM28. Each is linked with TMEM132A in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM132A-to-partner and partner-to-TMEM132A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFC5 grouped by TMEM132A-low versus TMEM132A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM132A→partner) and Y-score (partner→TMEM132A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RFC5 →	+0.659	+2.305	<.001	<.001	3	4
UCEC	CEP76 →	+0.482	+3.928	<.001	<.001	3	3
UCEC	RBM28 →	+0.314	+2.676	.003	<.001	3	3
UCEC	BCCIP →	+0.449	+3.222	<.001	<.001	3	3
UCEC	MTPAP →	+0.341	+2.040	.005	.005	3	3
UCEC	C1QBP →	+0.629	+3.115	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,954 associations by consensus.

RFC5 by TMEM132A expression — UCEC

Explore this box plot interactively →