TMEM132A

Across TCGA patient cohorts, TMEM132A mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM132A-associated genes across cancer lineages are GAPDH, eIF4E, and MYH11. Each is linked with TMEM132A in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM132A-to-partner and partner-to-TMEM132A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by TMEM132A-low versus TMEM132A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM132A→partner) and Y-score (partner→TMEM132A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.761	+2.820	.002	.035	3	4
UCEC	eIF4E →	+0.211	+2.392	.004	<.001	3	3
SKCM	MYH11 →	-0.649	-2.321	.029	.032	3	3
SKCM	Chk1 →	+0.179	+1.474	.006	.013	3	3
BLCA	ATM →	-0.463	-3.169	.022	.019	1	4
UCEC	EGFR_pY1068 →	-0.288	-2.392	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

GAPDH by TMEM132A expression — COAD

Explore this box plot interactively →