TMEM132A

Across TCGA cell cohorts, TMEM132A mutation is significantly associated with the RNA expression of many other genes, with 554 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM132A-associated genes across cancer lineages are KCNK18, RBMXL2, and MRGPRX1. Each is linked with TMEM132A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM132A-to-partner and partner-to-TMEM132A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNK18 grouped by TMEM132A-low versus TMEM132A-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM132A→partner) and Y-score (partner→TMEM132A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	KCNK18 →	+0.036	+5.000	<.001	.005	3	2
LARGE_INTESTINE	RBMXL2 →	+0.063	+2.217	<.001	.006	3	2
OESOPHAGUS	MRGPRX1 →	+0.175	+4.392	<.001	.003	3	1
OESOPHAGUS	AGBL1 →	+0.067	+4.392	<.001	.003	3	1
KIDNEY	OR5H6 →	+0.066	+5.000	<.001	.005	3	1
KIDNEY	MTRNR2L10 →	+0.013	+5.000	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 554 associations by consensus.

KCNK18 by TMEM132A expression — KIDNEY

Explore this box plot interactively →