TMEM131

Across TCGA pan-cancer cohorts, TMEM131 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TMEM131 data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TMEM131 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM131 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, UCS, and LUSC are the cancer types where TMEM131 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.979	0.606	<.001	34	view →
UCS	OS	Median	All	0.007	0.689	<.001	24	view →
LUSC	DFS	Median	II,III,IV	0.079	0.750	<.001	13	view →
BLCA	OS	Median	IV	0.239	0.619	<.001	12	view →
SKCM	OS	Median	IV	0.247	0.752	.004	7	view →
LUAD	DFS	Median	III,IV	0.036	0.673	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TMEM131–UCEC (DFS)

Open the UCEC breakdown →