TMEM126B

Across TCGA patient cohorts, TMEM126B protein abundance is significantly associated with the RNA expression of many other genes, with 7,562 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM126B-associated genes across cancer lineages are DNM3OS, SNX9, and YJEFN3. Each is linked with TMEM126B in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM126B-to-partner and partner-to-TMEM126B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM126B versus DNM3OS in PDAC, with a Pearson correlation of -0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM126B→partner) and Y-score (partner→TMEM126B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	DNM3OS →	-0.999	-0.514	.008	.008	3	4
PDAC	SNX9 →	-0.507	-0.593	<.001	.003	3	3
LSCC	YJEFN3 →	+0.648	+0.302	<.001	<.001	3	3
OV	PLIN2 →	-0.912	-0.370	.007	.001	3	3
LSCC	FIGN →	-0.882	-0.299	<.001	<.001	3	3
OV	CETN4P →	-0.212	-0.253	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,562 associations by consensus.

TMEM126B vs DNM3OS — PDAC

Explore this scatter interactively →