TMEM126B

Across TCGA pan-cancer cohorts, TMEM126B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TMEM126B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMEM126B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM126B is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

HNSC, LIHC, and KIRC are the cancer types where TMEM126B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM126B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.628	<.001	12	view →
LIHC	Male	II,III,IV	+0.767	<.001	9	view →
KIRC	All	All	+0.220	<.001	9	view →
KICH	All	II,III,IV	−0.721	<.001	8	view →
STAD	All	II,III,IV	+0.767	<.001	6	view →
COAD	All	II,III,IV	+0.465	.001	5	view →
LUSC	All	All	−0.252	.007	4	view →
CHOL	All	All	+1.133	<.001	3	view →
LUAD	Male	All	+0.349	.015	3	view →
THCA	All	All	−0.157	.005	3	view →
ESCA	All	All	+0.707	.006	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TMEM126B–HNSC

Open the HNSC breakdown →