TMEM126B

Across TCGA patient cohorts, TMEM126B mutation is significantly associated with the RNA expression of many other genes, with 2,036 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM126B-associated genes across cancer lineages are LINC01050, LINC01607, and DOC2B. Each is linked with TMEM126B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM126B-to-partner and partner-to-TMEM126B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01050 grouped by TMEM126B-low versus TMEM126B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM126B→partner) and Y-score (partner→TMEM126B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC01050 →	+0.292	+2.289	<.001	.001	3	1
UCEC	LINC01607 →	-0.855	-3.438	<.001	.005	3	1
UCEC	DOC2B →	-1.336	-3.438	<.001	.005	3	1
UCEC	WASL-DT →	+0.649	+3.374	<.001	.004	3	1
UCEC	LINC02091 →	-0.319	-3.831	.008	<.001	3	1
UCEC	CWC25 →	+0.501	+2.839	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,036 associations by consensus.

LINC01050 by TMEM126B expression — UCEC

Explore this box plot interactively →