TMEM126B

Across TCGA patient cohorts, TMEM126B mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM126B-associated genes across cancer lineages are JNK_pT183_Y185, JNK2, and PKC-b-II_pS660. Each is linked with TMEM126B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM126B-to-partner and partner-to-TMEM126B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by TMEM126B-low versus TMEM126B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM126B→partner) and Y-score (partner→TMEM126B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.163	-2.446	.046	.020	3	1
UCEC	JNK2 →	+0.333	+2.459	<.001	.020	3	1
UCEC	PKC-b-II_pS660 →	-0.277	-2.459	.038	.020	3	1
UCEC	Annexin-1 →	+0.656	+2.827	.009	.035	3	1
UCEC	STAT3_pY705 →	-0.434	-2.449	<.001	.019	3	1
UCEC	Tuberin →	+0.417	+3.179	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

JNK_pT183_Y185 by TMEM126B expression — UCEC

Explore this box plot interactively →