TMEM126B

Across TCGA cell cohorts, TMEM126B RNA expression is significantly associated with the go_rna of many other GO terms, with 2,698 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM126B-associated GO terms across cancer lineages are Asparaginyl-tRNA aminoacylation, Pyruvate decarboxylation to acetyl-CoA, and Mitochondrial protein quality control. Each is linked with TMEM126B in more than 11 cancer types. Because this analysis shows association rather than direction, both TMEM126B-to-partner and partner-to-TMEM126B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Asparaginyl-tRNA aminoacylation grouped by TMEM126B-low versus TMEM126B-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM126B→partner) and Y-score (partner→TMEM126B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Asparaginyl-tRNA aminoacylation →	+0.186	+1.138	<.001	<.001	3	12
LUNG_SCLC	Pyruvate decarboxylation to acetyl-CoA →	+0.132	+0.586	.001	.001	3	12
OVARY	Mitochondrial protein quality control →	+0.131	+0.863	.001	<.001	3	12
KIDNEY	Spindle checkpoint signaling →	+0.086	+0.513	.003	.008	3	10
PANCREAS	Regulation of mitotic recombination →	+0.108	+0.683	.002	.002	3	10
CNS	Mitotic spindle assembly checkpoint signaling →	+0.107	+0.652	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,698 associations by consensus.

Asparaginyl-tRNA aminoacylation by TMEM126B expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →