TMEM126A

Across TCGA patient cohorts, TMEM126A protein abundance is significantly associated with the RNA expression of many other genes, with 8,550 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMEM126A-associated genes across cancer lineages are R3HCC1L, RASSF1, and PNN. Each is linked with TMEM126A in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM126A-to-partner and partner-to-TMEM126A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM126A versus R3HCC1L in UCEC, with a Pearson correlation of -0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM126A→partner) and Y-score (partner→TMEM126A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	R3HCC1L →	-0.630	-0.380	<.001	<.001	3	4
UCEC	RASSF1 →	-0.718	-0.398	.001	<.001	3	4
PDAC	PNN →	-0.477	-0.370	<.001	<.001	3	4
BRCA	CCAR1 →	-0.364	-0.394	<.001	.001	3	4
UCEC	SMC3 →	-0.415	-0.337	.003	<.001	3	3
HNSC	SMC4 →	-0.646	-0.301	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,550 associations by consensus.

TMEM126A vs R3HCC1L — UCEC

Explore this scatter interactively →