TMEM126A

Across TCGA patient cohorts, TMEM126A mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM126A-associated genes across cancer lineages are RN7SKP181, KRTAP8-2P, and RNU6-956P. Each is linked with TMEM126A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM126A-to-partner and partner-to-TMEM126A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP181 grouped by TMEM126A-low versus TMEM126A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM126A→partner) and Y-score (partner→TMEM126A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP181 →	+0.196	+3.396	<.001	.006	3	2
UCEC	KRTAP8-2P →	+0.399	+4.937	<.001	<.001	3	2
HNSC	RNU6-956P →	+0.763	+7.954	<.001	.008	3	1
HNSC	OR11H3P →	+0.034	+7.954	<.001	.008	3	1
HNSC	MIR6786 →	+0.323	+7.954	<.001	.008	3	1
HNSC	MBD3L4 →	+0.059	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

RN7SKP181 by TMEM126A expression — UCEC

Explore this box plot interactively →