TMEM125

Across TCGA patient cohorts, TMEM125 mutation is significantly associated with the RNA expression of many other genes, with 1,395 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM125-associated genes across cancer lineages are RN7SL726P, MIR3619, and MIR620. Each is linked with TMEM125 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM125-to-partner and partner-to-TMEM125 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL726P grouped by TMEM125-low versus TMEM125-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM125→partner) and Y-score (partner→TMEM125) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL726P →	+0.168	+3.073	<.001	<.001	3	2
UCEC	MIR3619 →	+0.556	+2.188	<.001	.007	3	2
COAD	MIR620 →	+0.638	+4.917	<.001	.003	3	2
COAD	TRAJ57 →	+0.953	+3.957	<.001	.003	3	2
COAD	RN7SL479P →	+0.447	+4.547	<.001	.005	3	2
COAD	RN7SL174P →	+0.502	+4.283	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,395 associations by consensus.

RN7SL726P by TMEM125 expression — UCEC

Explore this box plot interactively →