TMEM125

Across TCGA cell cohorts, TMEM125 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,838 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TMEM125-associated GO terms across cancer lineages are Cellular response to indole-3-methanol, Negative regulation of Arp2/3 complex-mediated actin nucleation, and Regulation of mechanoreceptor differentiation. Each is linked with TMEM125 in more than 10 cancer types. Because this analysis shows association rather than direction, both TMEM125-to-partner and partner-to-TMEM125 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to indole-3-methanol grouped by TMEM125-low versus TMEM125-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM125→partner) and Y-score (partner→TMEM125) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Cellular response to indole-3-methanol →	+0.178	+1.898	.008	.009	3	11
BREAST	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.199	+3.068	<.001	<.001	3	11
LUNG_SCLC	Regulation of mechanoreceptor differentiation →	+1.144	+1.934	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Sensory perception of salty taste →	+1.882	+2.450	<.001	.002	3	10
LUNG_NSCLC_LUSC	Regulation of atrial cardiac muscle cell membrane depolarization →	-1.350	-1.910	<.001	.001	3	10
LUNG_NSCLC_LUSC	Cellular response to molecule of fungal origin →	+1.736	+2.212	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,838 associations by consensus.

Cellular response to indole-3-methanol by TMEM125 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →